Models of human disease through gene targeting.
نویسندگان
چکیده
25 eds.), vol. 2, pp. 227-241, John Wiley & Sons, Chichester Bolger, G. ( 1 994) Cell. Signalling 6.85 1-859 Beavo, J. A., Conti, M. and Heaslip, R. J. (1994) Mol. Endocrinol. 46,399-405 Shakur, Y., Pryde, J. and Houslay, M. D. (1993) Biochem. J. 292,677-686 Lobban, M., Shakur, Y.. Beattie, J. and Houslay. M. D. (1994) Biochem. J. 304,399-406 Shakur, Y., Wilson, M., Pooley, L.. Lobban, M., Grifliths, S. L., Campbell, A. M., Beattie, J., Daly, J, C. and Houslay, M. D. (1994) Biochem. J. 306,801-809 Sullivan, M., Egerton, M., Shakur. Y.. Marquardsen, A. and Houslay, M. D. (1994) Cell Signalling 6, 793-8 12 26 Wilson, M., Sullivan, M., Brown, N. and Houslay, M. D. (1994) Biochem. J. 304,407-415 27 Horton, Y. M., Sullivan, M. and Houslay, M. D. (1994) FASEB J. 8, A369 (Abstr. 21 36) 28 Houslay, M. D. and Lobban, M. (1994) FASEB J. 8, A369 (Abstr. 2134) 29 Livi, G. P., Kmetz, P., Mchale, M. M.. Cieslinski. L. B., Sathe, G. M., Taylor, D. P., Davis, R. L., Trophy, T. J. and Balcarek, J. M. (1990) Mol. Cell. Biol. 10. 2678-2686
منابع مشابه
Stem Cells Application in Modeling of Human Genetic Diseases
The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
متن کاملP-111: An Attempt to Facilitate the Production of Transgenic Mouse As A Model for Gene Therapy of Gaucher Disease
Background: Gaucher disease is an autosomal recessive inherited lysosomal storage disorder that affects many of the body's organs and tissues by defective function of the catabolic enzyme β-glucocerebrosidase. Gene therapy is one of the efficient ways for treatment of this disease. Due to the lack of appropriate animal models, in the field of gene therapy little progress has been done.Mate...
متن کاملmicroRNA-29a functions as a tumor suppressor in nasopharyngeal carcinoma 5-8F cells through targeting VEGF
Objective(s): microRNA-29 (miR-29) family miRNAs have been mentioned as tumor suppressive genes in several human cancers. The purpose of this study was to investigate the function of miR-29a in nasopharyngeal carcinoma (NPC) cells. Materials and Methods: Human NPC cell line 5-8F was transfected with mimic, inhibitor or scrambled controls...
متن کاملMicroRNA-205 inhibits renal cells apoptosis via targeting CMTM4
Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). In the present study, we elucidated the role of microR...
متن کاملThe Role of Interleukin (IL-22) in immune response to human diseases
Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. L-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. The aim of this study was to i...
متن کاملDevelopment of specific nanobodies (VHH) for CD19 immuno-targeting of human B-lymphocytes
Objective(s): CD19 is a transmembrane glycoprotein of immunoglobulin superfamily. In order to treat lymphoma, monoclonal antibodies (mAb) can target different antigens, including CD19, CD20 and CD22 on the surface of B-cells. Along with biotechnology progress, a new generation of antibodies is introduced, with the purpose of eliminating the defects of the previous generation. Among the most dev...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 23 2 شماره
صفحات -
تاریخ انتشار 1995